iRNAchek

A comprehensive solution to the challenge of siRNA Design


iRNAchek™ provides a comprehensive and intuitively designed environment for organization of sequence data, design of siRNAs, and tracking and analysis of successful templates.


OVERVIEW


Five great reasons to try OptGene™:


Intuitive Environment:


iRNAchek™ provides a comprehensive and intuitively designed environment for organization of sequence data, design of siRNAs, and tracking and analyzing successful templates.


Flexible Design:


Allows users flexibility to define their search templates, set regions of interest based on wide variety of criterion such as ORFs, UTR regions, introns and exons, secondary structures, motifs and domains, and post design analysis of successful siRNA.


Easy to learn:


User-friendly organization of features, GUIs and visualization tools which provide knowledge rather information.


Robust Analysis Capabilities:


iRNAchek™ has a unique tool that keeps track of successful templates and uses statistical techniques to convert information contained in siRNA fragments into knowledge.


24 X 5 Free Support:


Free Live web demonstration and post sale e-mail support for the life.

FEATURES


Search based on specific region


iRNAchek™ provides a facility to design the siRNA based on the regions of interest. These regions can be set based on Open Reading Frames, introns, exons, UTR regions and other sequence annotations. There is also a provision to eliminate templates from specific regions.


Motif Search


It is very essential to design siRNA targets that do not fall within functionally significant motifs and domains of the sequence. iRNAchek™ takes care of this efficiently by the use of a filter to refine the results based on Motif and Domain search.


Hairpin Loop search

HL_780

Efficiency of siRNA is sometimes affected by existence of stable hairpin loops. This tool identifies all possible hairpin loop formations and sorts them on the basis of their stabilization energy. User has an option to filter siRNA’s overlapping with selected hairpin loops.


Statistical Analysis


iRNAchek™ has a unique tool that keeps track of successful templates and uses statistical techniques to convert the information contained in siRNA fragments into knowledge. This tool helps the user to design targets with better


BLAST Tool


BT_780

iRNAchek™ helps the user select specific siRNA’s using intuitively designed BLAST tool. Using this tool the user can search for potential matches from NCBI database or can create his own proprietary database and search for matches against proprietary databases for possible matches.


Chemical Modifications


ChM_780

iRNAchek™ allows users to enhance siRNAs by allowing the user to define an implement chemical modification rules. The user can change overhang length, vary bases of overhangs to include deoxy bases, modify the molecule backbone, sugar groups, individual nucleotide bases including terminal bases and further. These modifications may be applied by position, by base, and by strand.


siRNA library


iRNAchek™ provides a user a library to store designed siRNA templates, along with any modification done. A set of siRNA selection filters, are given to the user for enabling performance analysis.

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